Chemistry is not destiny, certainly. But these scientists have demonstrated that the most reliable way to produce an adult who is brave and curious and kind and prudent is to ensure that when he is an infant, his hypothalami-pituitary-adrenal axis functions well. And how do you do that? It is not magic. First, as much as possible, you protect him from serious trauma and chronic stress; then, even more important, you provide him with a secure, nurturing relationship with at least one parent and ideally two. That's not the whole secret of success, but it is a big, big part of it.

— Paul Tough

The part of the brain most affected by early stress is the prefrontal cortex, which is critical in self-regulatory activities of all kinds, both emotional and cognitive. As a result, children who grow up in stressful environments generally find it harder to concentrate, harder to sit still, harder to rebound from disappointments, and harder to follow directions. And that has a direct effect on their performance in school.

— Paul Tough